The world's most reputed pharmaceutical company, Pfizer, is on the mission to help men all over the world with erectile dysfunction to achieve satisfactory erection through its famous drug Viagra. Despite the increasing competition in the world of drug industry, Pfizer stands tall producing Viagra since 1998. Pfizer's Viagra has gained rapid popularity in adults because of its promising results and dependable quality. Viagra has found to help men of every age group suffering from erectile dysfunction. Today more and more men are falling victim to impotence because of nutritional deficiencies and emotional traumas, so Viagra is gaining increased importance day by day.
As Viagra enters the blood, it targets phosphodiesterase which is an enzyme present in blood vessels of the penis having the job to break down cGMP which has a relaxant effect on penile muscles. As PDE is blocked by Viagra, the level of cGMP increases which relaxes muscles of penis resulting in greater inflow of blood leading to erection. The men suffering from impotence are unable to raise their cGMP level enough to cause muscle relaxation which is necessary for erection. When a person is sexually stimulated, his endothelial cells release Nitric Oxide (NO) into the vessels of the penis, This Nitric Oxide has the function of activating guanylyl cyclase, an enzyme having the duty of converting GTP into cGMP which plays the key role in erection by relaxing penile muscles so that blood could enter in these muscles to cause erection. One striking feature of this drug action is that it does not increase cGMP level by stimulating its increased production, rather than that it raises cGMP level by blocking its destruction from PDE.
If you see Viagra, it will be a diamond shaped blue colored tablet having its potency written on one side and Pfizer on the other side. It is available in various dosages like 25mg, 50mg, and 100mg tablets. Physicians usually start their patients from 25mg dose, but the most commonly prescribed dose once started is 50mg.For older men, always a dose of 25mg is recommended. It is advised to not take the pill more than once in 24 hours. The tablet is consumed about 30min before engaging in sexual activity. The drug provides its action for about 4 hours.
If a person is taking Viagra, he should not take Beta blockers, Protease Inhibitors and Erythromycin. Nitrates should also be avoided as they increase the risk of hypotension. Over dosage of Viagra can result in decreased blood pressure which might prove fatal. Side effects of Viagra include dizziness, diarrhea, dyspepsia, flushing, headache and visual impairments. Another side effect encountered is priapism-a condition in which muscles of the penis undergo prolonged painful erection. If you face any of these symptoms while using Viagra, immediately stop using it and consult your doctor. Those patients who have a history of cardiac, hepatic and kidney problems are advised to take Viagra only after consulting physician.
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